Доказанные эффекты Дипептивена

Включены только исследования уровня «доказательной силы» А - проспективные рандомизированные исследования (по Agency for Healthcare Research and Quality, US Department of Health and Human Services)

Абдоминальный
сепсис Снижение летальности (APACHE II > 11)

  • Griffiths RD, et al.. Six month outcome of critically ill patients given glutamine supplemented parenteral nutrition. Nutrition 13:295-302; 1997 Снижение затрат на лечение в ОРИТ на 25% (APACHE II > 11)
  • Griffiths RD, et al.. Six month outcome of critically ill patients given glutamine supplemented parenteral nutrition. Nutrition 13:295-302; 1997 Снижение частоты инфекционных осложнений
  • Dechelotte Pet al. Improved clinical outcome in ICU patients receiving alanylglutamine (Dipeptiven ) supplemented total parenteral nutrition (TPN). A french double-blind multicenter study. ESPEN 2002
  • Griffiths RD, et al. Infection, multiple organ failure, and survival in the intensive care unit: influence of glutamine-supplemented parenteral nutrition on acquired infection. Nutrition 2002 Jul-Aug;18(7-8):546-52 Большие
    абдоминальные
    операции Улучшение азотистого баланса:
  • Morlion BJ, et al. Total parenteral nutrition with glutamine dipeptide after major abdominal surgery: a randomized, double-blind, controlled study. Ann Surg 1998 Feb;227(2):302-8
  • Stehle P. et al. Effect of parenteral glutamine peptide supplements in muscle glutamine loss and nitrogen balance after major surgery. Lancet 1989;i: 231-233.
  • Hammarqvist et al. Alanyl-glutamine counteracts the depletion of free glutamine and the postoperative decline in protein synthesis in skeletal muscle. Ann. Surg. 1990; 212: 637-644.
  • Jiang ZM, et al. The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients. JPEN J Parenter Enteral Nutr 1999 Sep-Oct;23(5 Suppl):S62-6 Улучшение функции кишки
  • Jiang ZM, et al. The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients. JPEN J Parenter Enteral Nutr 1999 Sep-Oct;23(5 Suppl):S62-6 Снижение продолжительности госпитализации
  • Morlion BJ, et al. Total parenteral nutrition with glutamine dipeptide after major abdominal surgery: a randomized, double-blind, controlled study. Ann Surg 1998 Feb;227(2):302-8
  • Jiang ZM, et al. The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients. JPEN J Parenter Enteral Nutr 1999 Sep-Oct;23(5 Suppl):S62-6
  • Powell-Tuck J et al. A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition. Gut 1999 Jul;45(1):82-8 Снижение летальности
  • Powell-Tuck J et al. A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition. Gut 1999 Jul;45(1):82-8
  • Griffiths RD, Jones C, Palmer TEA. Six month outcome of critically ill patients given glutamine supplemented parenteral nutrition. Nutrition 3:295-302; 1997 Снижение затрат на лечение
  • Mertes N. Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study. Clin Nutr. 2000 Dec;19(6):395-401. Снижение частоты осложнений
  • Jacobi et al. 4th International Congress on the Immune Consequences of Trauma, Shock, and Sepsis. Munich, 4-8 March 1997. Перитонит Снижение летальности
  • Goeters, C. et al. Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients. Critical Care Medicine 2002; 30: 2032-2037. Снижение продолжительности госпитализации
  • Ockenga et al. A randomised, controlled trial of glutamine supplementation in gastroenterological patients scheduled for parenteral nutrition. Digestive Disease Week (DDW), San Diego 2000 Снижение затрат на лечение
  • Ockenga et al. A randomised, controlled trial of glutamine supplementation in gastroenterological patients scheduled for parenteral nutrition. Digestive Disease Week (DDW), San Diego 2000,. Улучшение функции кишки и улучшение азотистого баланса
  • Jiang ZM, et al. The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients. JPEN J Parenter Enteral Nutr 1999 Sep-Oct;23(5 Suppl):S62-6 - А.Е.Шестопалов и др. ГЛУТАМИН ДИПЕПТИД (Дипептивен®) В ПОЛНОМ ПАРЕНТЕРАЛЬНОМ ПИТАНИИ ПРИ КРИТИЧЕСКИХ СОСТОЯНИЯХ. Вестник интенсивной терапии, 2003 №1 Стимуляция иммунитета
  • Siedhoff et al. Unterstützung des Immunsystems durch Glutamin- Dipeptid-supplementierte totale parenterale Ernährung (TPN) nach Dickdarmchirurgie. Abstract-Band DAK Nürnberg, 19-22 June 1996.
  • А.Е.Шестопалов и др. ГЛУТАМИН ДИПЕПТИД (Дипептивен®) В ПОЛНОМ ПАРЕНТЕРАЛЬНОМ ПИТАНИИ ПРИ КРИТИЧЕСКИХ СОСТОЯНИЯХ. Вестник интенсивной терапии, 2003 №1 Политравма Снижение частоты инфекционных осложнений
  • Dechelotte Pet al. Improved clinical outcome in ICU patients receiving alanylglutamine (Dipeptiven ) supplemented total parenteral nutrition (TPN). A french double-blind multicenter study. ESPEN 2002 Снижение резистентности к инсулину
  • Bakalar B, et al. Parenteral glutamine attenuates insulin resistance in multiple trauma patients. Annual Congress of the European Society of Intensive Care Medicine, Amsterdam, October 5-8, 2003 Снижение летальности
  • Powell-Tuck J et al. A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition. Gut 1999 Jul;45(1):82-8
  • Goeters, C. et al. Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients. Critical Care Medicine 2002; 30: 2032-2037. Панкреатит Снижение частоты осложнений
  • Dechelotte Pet al. Improved clinical outcome in ICU patients receiving alanylglutamine (Dipeptiven ) supplemented total parenteral nutrition (TPN). A french double-blind multicenter study. ESPEN 2002
  • Griffiths RD, et al. Infection, multiple organ failure, and survival in the intensive care unit: influence of glutamine-supplemented parenteral nutrition on acquired infection. Nutrition 2002 Jul-Aug;18(7-8):546-52 Снижение летальности
  • Griffiths RD, Jones C, Palmer TEA. Six month outcome of critically ill patients given glutamine supplemented parenteral nutrition. Nutrition 13:295-302; 1997 Снижение выброса провоспалительных цитокинов (IL-8 и др.)
  • De Beaux et al. Glutamine-supplemented total parenteral nutrition reduces blood mononuclear cell interleukin-8 release in severe acute pancreatitis. Nutrition 1998; 14: 261-265. Коррекция воспалительной реакции (уровень CRP IM)
  • Ockenga et al. Einfluß einer glutaminsupplementierten, total parenteralen Ernährung auf den Verlauf von Pankreatitiden. Akt. Ernähr.-Med. 1999; 24: 52. Колоректальные
    опухоли Снижение атрофии слизистой ЖКТ и мукозитов, вызванных химиотерапией.
  • C. Decker-Baumann et al. Reduction of Chemotherapy-induced Side-efIects by Parenteral Glutamine Supplementation in Patients with Metastatic Colorectal Cancer. Europeon Journal of Cancer, Vol. 35, No. 2, pp. 202-207, 1999 Улучшение функции кишки
  • Van der Hulst et al. Glutamine and the preservation of gut integrity. Lancet 1993; 341: 1363-1365. Стимуляция иммунитета
  • O´Riordain et al. Glutamine-supplemented total parenteral nutrition enhances T-lymphocyte response in surgical patients undergoing colorectal resection. Ann. Surg. 1994; 220: 212-221. Тяжелые ожоги Снижение частоты бактериемии.
  • Paul E. Wischmeyer, at al. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: A prospective, randomized, double-blind trial versus isonitrogenous control/ Crit Care Med 2001 Vol. 29, No. 11 Снижение частоты инфекционных осложнений
  • Griffiths RD, et al. Infection, multiple organ failure, and survival in the intensive care unit: influence of glutamine-supplemented parenteral nutrition on acquired infection. Nutrition 2002 Jul-Aug;18(7-8):546-52 Снижение летальности
  • Griffiths RD, Jones C, Palmer TEA. Six month outcome of critically ill patients given glutamine supplemented parenteral nutrition. Nutrition 13:295-302; 1997 Пересадка костного мозга /онкогематология Снижение летальности
  • Powell-Tuck J et al. A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition. Gut 1999 Jul;45(1):82-8 Снижение продолжительности госпитализации
  • Nutrition support for bone marrow transplant patients (Cochrane Review) From The Cochrane Library, Issue 4, 2003
  • Ziegler TR, et al. Clinical and metabolit efficacy of glutamine supplemented parenteral nutrition after bone marrow transplantation. Ann Intern Med 116:821-828, 1992, 2002 Снижение затрат на лечение
  • McBurney et al. A cost-evaluation of glutamine-supplemented parenteral nutrition in adult bone marrow transplantation. J.Am.Diet,Assoc. 1994; 94:1263-1266, Снижение частоты инфекционных осложнений
  • Ziegler TR, et al. Clinical and metabolit efficacy of glutamine supplemented parenteral nutrition after bone marrow transplantation. Ann Intern Med 116:821-828, 1992 Улучшение азотистого баланса:
  • McBurney et al. A cost-evaluation of glutamine-supplemented parenteral nutrition in adult bone marrow transplantation. J.Am.Diet,Assoc. 1994; 94:1263-1266,

  • Total Execution Time: 3.7038326263428 ms